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KMID : 0379520150310010061
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한국독성학회지
2015 Volume.31 No. 1 p.61 ~ p.68
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Single Oral Dose Toxicity Test of Blue Honeysuckle Concentrate in Mice
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Kim Hyung-Soo
Park Sang-In
Choi Seung-Hoon
Song Chang-Hyun
Park Soo-Jin
Shin Yong-Kook
Han Chang-Hyun
Lee Young-Joon
Ku Sae-Kwang
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Abstract
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The objective of this study was to obtain single oral dose toxicity information for concentrated and lyophilized powder of blue honeysuckle (Lonicera caerulea L., Caprifoliaceae; BHcL) in female and male ICR mice to aid in the process of developing natural origin medicinal ingredients or foods following proximate analysis and phytochemical profile measurement. The proximate analysis revealed that BHcL had an energy value of 3.80 kcal/g and contained 0.93 g/g of carbohydrate, 0.41 g/g of sugar, 0.02 g/g of protein, and 0.20 mg/g of sodium. BHcL did not contain lipids, including saturated lipids, trans fats, or cholesterols. Further, BHcL contained 4.54% of betaine, 210.63 mg/g of total phenols, 159.30 mg/g of total flavonoids, and 133.57 mg/g of total anthocyanins. Following administration of a single oral BHcL treatment, there were no treatment-related mortalities, changes in body weight (bw) or organ weight, clinical signs, necropsy or histopathological findings up to 2,000 mg/kg bw, the limited dosage for rodents of both sexes. We concluded that BHcL is a practically non-toxic material in toxicity potency.
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KEYWORD
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Single oral dose toxicity, Mouse, Blue honeysuckle, Proximate analysis, Phytochemical analysis
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